Sildenafil is actually a strong and selective inhibitor of cGMP-particular phosphodiesterase variety 5 (PDE5), which is responsible for degradation of cGMP in the corpus cavernosum. The molecular framework of sildenafil is analogous to that of cGMP and acts for a aggressive binding agent of PDE5 in the corpus cavernosum, leading to more cGMP and en… Read More